Endocervically administered PREPIDIL Gel is not recommended for the following:
- Patients in whom oxytocic drugs are generally contraindicated or where prolonged contractions of the uterus are considered inappropriate, such as:
- cases with a history of cesarean section or major uterine surgery
- cases in which cephalopelvic disproportion is present
- cases in which there is a history of difficult labor and/or traumatic delivery
- grand multiparae with six or more previous term pregnancies cases with non-vertex presentation
- cases with hyperactive or hypertonic uterine patterns
- cases of fetal distress where delivery is not imminent
- in obstetric emergencies where the benefit-to-risk ratio for either the fetus or the mother favors surgical intervention
- Patients with hypersensitivity to prostaglandins or constituents of the gel (see WARNINGS and ADVERSE REACTIONS).
- Patients with placenta previa or unexplained vaginal bleeding during this pregnancy.
- Patients for whom vaginal delivery is not indicated, such as vasa previa or active herpes genitalia.