Paxlovid™ (Nirmatrelvir/ritonavir)

Find PAXLOVID™ medical information:

Find PAXLOVID™ medical information:

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PAXLOVID™ (nirmatrelvir tablets; ritonavir tablets), co‑packaged for oral use (also known as PAXLOVID™ (Nirmatrelvir; ritonavir))

The following Gulf countries (UAE, Oman, Bahrain, Qatar and Kuwait) authorizations are based on the Local Regulatory Authorities' Emergency Use Authorization for PAXLOVID

What allergens/ingredients Paxlovid™ contains?

What are the ingredients in Paxlovid?


Nirmatrelvir

Tablet core: microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, colloidal silicon dioxide, sodium stearyl fumarate. Film-coat:hydroxy propyl methylcellulose (E464), titanium dioxide (E171), polyethylene glycol (E1521), iron oxide red (E172).

Ritonavir

Tablet core: copovidone, sorbitan laureate, silica, colloidal anhydrous, calcium hydrogen phosphate, anhydrous, sodium stearyl fumarate. Film-coat: hypromellose (E464), titanium dioxide (E171), macrogol, hydroxypropyl cellulose (E463), talc (E553b), silica, colloidal anhydrous (E551), polysorbate 80 (E433).

For information regarding other allergen/ingredients, please contact Medical Information at www.pfizermedicalinformationgulf.com or contact our Medical Information team on contact us.


Does Paxlovid contain lactose?


Each Nirmatrelvir 150 mg film-coated tablet contains 176 mg of lactose. Patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption should not take this medicine.

We cannot guarantee that minute amounts of substances are not contained in raw materials obtained from our suppliers. To ensure we have a consistent and reliable supply of medications, we must use a network of suppliers and manufacturing sites globally for both active and inactive ingredients.

For information regarding other allergen/ingredients, please contact Medical Information at www.pfizermedicalinformationgulf.com or contact our Medical Information team on contact us.


Does Paxlovid contain sodium?


Nirmatrelvir and ritonavir each contain less than 1 mmol sodium (23 mg) per dose, that is to say essentially ‘sodium free’.

We cannot guarantee that minute amounts of substances are not contained in raw materials obtained from our suppliers. To ensure we have a consistent and reliable supply of medications, we must use a network of suppliers and manufacturing sites globally for both active and inactive ingredients.

For information regarding other allergen/ingredients, please contact Medical Information at www.pfizermedicalinformationgulf.com or contact our Medical Information team on contact us.

Why should Nirmatrelvir be used in combination with Ritonavir?

Ritonavir is administered with Nirmatrelvir as a pharmacokinetic enhancer resulting in higher systemic concentrations of Nirmatrelvir.

Ritonavir is not active against the SARS-CoV-2 3CL protease. Ritonavir inhibits the CYP3A-mediated metabolism of Nirmatrelvir, thereby providing increased plasma concentrations of Nirmatrelvir.

In healthy participants, the mean half-life of a single dose of 150 mg Nirmatrelvir administered alone was approximately 2 hours compared to 7.5 hours after administration of a single dose of 250 mg/100 mg dose of Nirmatrelvir/ritonavir thereby supporting a twice‑daily administration regimen.

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Reporting an adverse event for PAXLOVID

Drug Safety Unit

In the event of a suspected adverse event or side effect with no associated medical information enquiry, please contact  [email protected]. Please always specify your country (i.e. Bahrain, Kuwait, Qatar, Oman, UAE.). If you have a medical information enquiry including those with associated adverse events, contact Medical Information.